The Systemic Response to Topical Aldara Treatment is Mediated Through Direct TLR7 Stimulation as Imiquimod Enters the Circulation

Abstract Topical application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely used mouse model for investigating the pathogenesis of psoriasis.We have previously used this model to study the effects of peripheral inflammation on the brain, and reported a brain-specific response characterised by increased transcr

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Constructing more comprehensive pollination networks: integrating diurnal and nocturnal pollen data with visitation in a subalpine wetland community

IntroductionSampling for describing plant–pollinator interaction networks has been performed using techniques that either focus on the plants (with flower-visit data) or the animals (with analyzing pollen on the body surface of flower visitors).The differences in the structure of the networks obtained using Commercial Vacuum Cleaner these methods

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Safer opioid supply: qualitative program evaluation

Abstract Background As the overdose crisis in copyright continues to escalate in severity, novel interventions and programs are required.Safer Supply programs offer pharmaceutical-grade medication to people who use drugs to replace and decrease harms related to the toxic illicit drug supply.Given the paucity of research surrounding these programs,

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